There are a number of errors that can happen when an organism develops from an embryo to an adult. A single missing cell or a cell out of place can have catastrophic results for the matured individual. Even a slightly altered rate of cell division at such an early stage is more likely to cause […]
Control over the genome and the epigenome has continued to be a prime focal point for the fields of science. New genome editing technologies and their related epigenetic tools has only exacerbated this spotlight. However, there are other areas of expression control that are available and some techniques, such as RNA interference (RNAi), seem to […]
Gene editing itself has truly just been the start of the modern biotechnological revolution. As time has passed, the nuance of capability with tools like CRISPR has evolved to not only be more precise, but to also have additional options beyond just additions or deletions of genes. New versions have included things like inducing point […]
When it comes to gene editing technologies like CRISPR, the initial applications were focused around just that, the capability to edit and alter gene sequences. The main efforts after were to enhance the specificity of this activity and to improve further what could be changed. But in recent years we’ve begun to see an expansion […]
The ability to make stem cells from other cell types has largely been a recent phenomenon. It took a huge amount of research and testing to get to that point and, even today, it requires a complex cocktail of chemicals to induce the needed genetic and epigenetic changes that revert a cell to its infancy. […]
Abstract By Brigette Corder, Sterling Ericsson, and Taylor Uhlir The CRISPR-Cas systems are a new and exciting tool for research and scientific discovery. Here we discuss and compare the various CRISPR-Cas systems and report current uses for these systems by concentrating a principal spotlight on CRISPR-Cas 10. From CRISPR’s rudimentary beginnings in the form of […]
Not every genetic modification has to involve a violent cleaving of nucleotides to insert or remove sections of the genome. The most common form this type of change takes involves what are termed double-strand breaks (DSBs) and they have long been something that scientists have wanted to avoid if possible. You may remember us discussing […]
Decoding the impact of genetic manipulation is a convoluted task. When it comes to investigating multi-layered diseases like Parkinson’s, it is fully expected that a whole host of genes in sequence or applied in simultaneity are used to promote onset of the disease. The process of figuring out which genes are involved or, conversely, which […]
