Phi X 174 slice

Structure and Potential of the CRISPR-Cas 10 System

Abstract By Brigette Corder, Sterling Ericsson, and Taylor Uhlir The CRISPR-Cas systems are a new and exciting tool for research and scientific discovery. Here we discuss and compare the various CRISPR-Cas systems and report current uses for these systems by concentrating a principal spotlight on CRISPR-Cas 10. From CRISPR’s rudimentary beginnings in the form of […]

Compact bone - ground cross section

Dead CRISPR-Cas9 Upgraded To Treat Genetic Disorders With No Gene Editing

Not every genetic modification has to involve a violent cleaving of nucleotides to insert or remove sections of the genome. The most common form this type of change takes involves what are termed double-strand breaks (DSBs) and they have long been something that scientists have wanted to avoid if possible. You may remember us discussing […]

Hippocampal neurons in culture

Buildup of Toxic Parkinson’s Protein Averted With CRISPR Screening

Decoding the impact of genetic manipulation is a convoluted task. When it comes to investigating multi-layered diseases like Parkinson’s, it is fully expected that a whole host of genes in sequence or applied in simultaneity are used to promote onset of the disease. The process of figuring out which genes are involved or, conversely, which […]

Embryonic smooth muscle cell

Correcting Muscular Dystrophy With CRISPR and Gold Nanoparticles

Being one of the earliest focused upon diseases for CRISPR to treat other than retinitis, Duchenne muscular dystrophy has seen a lot of scientific effort be put into finding a cure or at least a palliative treatment to restore some amount of strength. Previous attempts have involved various types of viral vectors to help remove […]

Mouse embryo

CRISPR Discovers Embryo Gene’s Fate And The Futility Of Mice Models

The field of embryology continues to be one with more mysteries than answers. Since it is difficult in many countries around the world to work directly with human embryos, animal models are often the best we can do. To a certain extent, stem cells allow us to at least observe the earliest stages of multicellular […]

PharbitisNil

Scientists Use CRISPR To Reinvent Traditional Japanese Flower

As things change, they ultimately stay the same. Or perhaps a better metaphor is that we always end up circling back to the beginning, retracing our own footsteps. That seems to be the case today, though not in a bad way. The Early Bloom One of the very first original biotech experiments back in the […]

Neuron-matrix

RNA-Targeting CRISPR-Cas9 Cures Neurological Diseases In Living Cells

The research into new forms of CRISPR seems never-ending. It is an ongoing goal of scientists around the world to expand scientific knowledge on different kinds of CRISPR and also creating newfound capabilities for the existing varieties. Since the greater the flexibility of the tools available to science, the more treatments and medicines that can […]

SK8-18-2 human derived cells, fluorescence microscopy (29942101073)

An Official CRISPR Library For Genetic Silencing Guidance

While genetic modification tools like CRISPR have opened up new doors to making changes to genomes, it is still not as simple of a task as putting the CRISPR complex into a cell and having it go to work. It first must be given a target DNA sequence to focus on and, in most cases, […]

Tribolium castaneum87-300

CRISPR Gene Drive Resistance Due To Inbreeding And Mutations

In a previous article, we discussed how CRISPR is not almighty and that organisms can evolve resistance to the changes made to their genome. The simplest method for them to accomplish this is just to mutate the changed gene back to what it was before or just stop its function altogether. If the change made […]

Rat primary cortical neuron culture, deconvolved z-stack overlay (30614937102)

CRISPR-Cas9 Allows Photographic Imaging Of Genes In Live Cells

Imaging cellular processes has always been difficult. With biotechnology, we have been able to use marker genes like green fluorescent protein (GFP) to follow the activities of individual cells, but that is a far cry from interior mechanisms within a cell. Since the dawn of the field, technology has advanced so that fluorescent microscopy has […]