Early embryonic development of Encarsia pergandiella. Nature as art or vice versa?

Mapping Cell Lineages Using CRISPR Cas9-Based Genetic Scarring

There are a number of errors that can happen when an organism develops from an embryo to an adult. A single missing cell or a cell out of place can have catastrophic results for the matured individual. Even a slightly altered rate of cell division at such an early stage is more likely to cause […]

Hops-1

GMO Yeast Helps Produce Hops-Less Beer To Mitigate Climate Effects

The process of beer-making is complicated. The brewing process has an array of steps that need to be followed fairly precisely or you risk ruining the flavor of your concoction. A general description of the process is that brewer’s yeast, usually specially cultivated strains of the model organism Saccharomyces cerevisiae, is used along with sugars […]

Neuron cluster

New CRISPR Tool Manipulates RNA Splicing to Control the Transcriptome

Control over the genome and the epigenome has continued to be a prime focal point for the fields of science. New genome editing technologies and their related epigenetic tools has only exacerbated this spotlight. However, there are other areas of expression control that are available and some techniques, such as RNA interference (RNAi), seem to […]

Müürlooga õie stigma

Epimutagenesis Controls DNA Methylation To Reveal Hidden Plant Traits

Properly breeding a plant for the traits you want is hard. It requires hundreds of plants and hundreds of cross-breeding attempts between them to obtain desired traits, isolate them, and cross them into more vigorous cultivars with other wanted traits. That was how it was done for most of human history and it’s a long, […]

HIV-budding-Color

CRISPR RNP Alteration Proves Key To Avoiding Human Immune Response

Gene editing itself has truly just been the start of the modern biotechnological revolution. As time has passed, the nuance of capability with tools like CRISPR has evolved to not only be more precise, but to also have additional options beyond just additions or deletions of genes. New versions have included things like inducing point […]

Influenza virus particle color

CRISPR Cas12 Used To Make An Accurate Viral Infection Detector

When it comes to gene editing technologies like CRISPR, the initial applications were focused around just that, the capability to edit and alter gene sequences. The main efforts after were to enhance the specificity of this activity and to improve further what could be changed. But in recent years we’ve begun to see an expansion […]

Phi X 174 slice

Structure and Potential of the CRISPR-Cas 10 System

Abstract By Brigette Corder, Sterling Ericsson, and Taylor Uhlir The CRISPR-Cas systems are a new and exciting tool for research and scientific discovery. Here we discuss and compare the various CRISPR-Cas systems and report current uses for these systems by concentrating a principal spotlight on CRISPR-Cas 10. From CRISPR’s rudimentary beginnings in the form of […]

Compact bone - ground cross section

Dead CRISPR-Cas9 Upgraded To Treat Genetic Disorders With No Gene Editing

Not every genetic modification has to involve a violent cleaving of nucleotides to insert or remove sections of the genome. The most common form this type of change takes involves what are termed double-strand breaks (DSBs) and they have long been something that scientists have wanted to avoid if possible. You may remember us discussing […]

Hippocampal neurons in culture

Buildup of Toxic Parkinson’s Protein Averted With CRISPR Screening

Decoding the impact of genetic manipulation is a convoluted task. When it comes to investigating multi-layered diseases like Parkinson’s, it is fully expected that a whole host of genes in sequence or applied in simultaneity are used to promote onset of the disease. The process of figuring out which genes are involved or, conversely, which […]