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Structure and Potential of the CRISPR-Cas 10 System

Abstract By Brigette Corder, Sterling Ericsson, and Taylor Uhlir The CRISPR-Cas systems are a new and exciting tool for research and scientific discovery. Here we discuss and compare the various CRISPR-Cas systems and report current uses for these systems by concentrating a principal spotlight on CRISPR-Cas 10. From CRISPR’s rudimentary beginnings in the form of […]

Compact bone - ground cross section

Dead CRISPR-Cas9 Upgraded To Treat Genetic Disorders With No Gene Editing

Not every genetic modification has to involve a violent cleaving of nucleotides to insert or remove sections of the genome. The most common form this type of change takes involves what are termed double-strand breaks (DSBs) and they have long been something that scientists have wanted to avoid if possible. You may remember us discussing […]

Asco Candida albicans

Gene Editing Tool Allows Dozens Of Modifications Without DNA Cleavage

The benefits of modern gene editing techniques and tools come with some downsides. While the precision of new and improved CRISPR systems is continually on the rise, there are some fundamental aspects of the tools that scientists have long wished we could work around, in order to reduce even the most minimal risk of off-target […]

Human Cell

Targeted RNA Changes With New CRISPR Tool Subvert Genetic Concerns

Specificity and efficiency in targeting is one of the hallmark aims of any CRISPR system. The ability to edit a genome is useless without the capability to target a particular sequence and reliably alter it. Thus, work has been perpetually ongoing in the hunt to find better CRISPR systems or to even design one from […]

Hippocampal neurons in culture

Buildup of Toxic Parkinson’s Protein Averted With CRISPR Screening

Decoding the impact of genetic manipulation is a convoluted task. When it comes to investigating multi-layered diseases like Parkinson’s, it is fully expected that a whole host of genes in sequence or applied in simultaneity are used to promote onset of the disease. The process of figuring out which genes are involved or, conversely, which […]

Embryonic smooth muscle cell

Correcting Muscular Dystrophy With CRISPR and Gold Nanoparticles

Being one of the earliest focused upon diseases for CRISPR to treat other than retinitis, Duchenne muscular dystrophy has seen a lot of scientific effort be put into finding a cure or at least a palliative treatment to restore some amount of strength. Previous attempts have involved various types of viral vectors to help remove […]

Mouse embryo

CRISPR Discovers Embryo Gene’s Fate And The Futility Of Mice Models

The field of embryology continues to be one with more mysteries than answers. Since it is difficult in many countries around the world to work directly with human embryos, animal models are often the best we can do. To a certain extent, stem cells allow us to at least observe the earliest stages of multicellular […]

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The Relaxed System of CRISPR-Cas10 Is Deadly To Mutated Viruses

The specificity found within the mechanisms of the CRISPR system can be both a boon and a bane. Thanks to things like the PAM sequence, CRISPR-Cas9 has found itself as a useful tool to accurately target desired gene sequences at an unparalleled level. No other gene editing technology can really come close to matching the […]

PharbitisNil

Scientists Use CRISPR To Reinvent Traditional Japanese Flower

As things change, they ultimately stay the same. Or perhaps a better metaphor is that we always end up circling back to the beginning, retracing our own footsteps. That seems to be the case today, though not in a bad way. The Early Bloom One of the very first original biotech experiments back in the […]

Neuron-matrix

RNA-Targeting CRISPR-Cas9 Cures Neurological Diseases In Living Cells

The research into new forms of CRISPR seems never-ending. It is an ongoing goal of scientists around the world to expand scientific knowledge on different kinds of CRISPR and also creating newfound capabilities for the existing varieties. Since the greater the flexibility of the tools available to science, the more treatments and medicines that can […]